Phenylbutazone (PBZ), commonly known as Bute, can be the horse owner's (and horse's) best friend. This popular and economical non-steroidal anti-inflammatory (NSAID) blocks pain, reduces swelling.. Phenylbutazone is FDA approved for use with horses and is a prescription drug. U. S. federal law restricts this drug to use by or on the lawful written or oral order of a licensed veterinarian. Phenylbutazone is a regulated or prohibited substance in most sanctioned competitions. In each case, the proper regulatory group should be consulted.

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Bute for Horses Dosage. Phenylbutazone is a potent compound classified as a non-steroidal anti-inflammatory drug. It aids in relieving pain and fever in horses. However, the drug is associated with various side effects such as ulcers of the gastrointestinal tract and urinary tract infection.. However, care should be taken as it may also mask other symptoms of an ill horse. Recomended dosage of bute: Day 1 - (8.8mg/kg per day) Days 2 -5 (4.4mg/kg per day): Side effects of phenylbutazone. Bute works well for horses for short-term pain relief. But it can be toxic if used in too high of a dose.